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Re(de)fining Innate Lymphocyte Lineages in the Face of Cancer.
- Source :
-
Cancer immunology research [Cancer Immunol Res] 2018 Apr; Vol. 6 (4), pp. 372-377. - Publication Year :
- 2018
-
Abstract
- Innate lymphocytes play critical roles in maintaining tissue homeostasis and integrity of the host at steady state and during pathogenic insults. The successive identification of new innate lymphocyte subsets has revealed an incredible diversity within the family. While this heterogeneous population can be grouped based on their cytotoxic potential into exclusively cytokine-producing helpers and cytolytic killers, the exact developmental relationships between the subsets are not fully understood. The former group is enriched at mucosal surfaces, whereas innate lymphocytes with cytotoxic potential can be identified in a wider array of tissues, including tumors. Although their cytotoxicity suggests an antitumor role, the nature of tumor-elicited innate lymphocyte responses has only begun to be investigated, and the identities of participating subsets still remain contentious. In this review, we provide a brief overview of innate lymphocyte biology, review the current knowledge on their ontogeny, and discuss their roles in tumor immunosurveillance. Cancer Immunol Res; 6(4); 372-7. ©2018 AACR .<br /> (©2018 American Association for Cancer Research.)
- Subjects :
- Animals
Biomarkers
Cytokines metabolism
Cytotoxicity, Immunologic
Disease Susceptibility
Humans
Lymphocyte Subsets metabolism
Lymphocytes, Tumor-Infiltrating immunology
Lymphocytes, Tumor-Infiltrating metabolism
Neoplasms metabolism
Neoplasms pathology
Organ Specificity genetics
Organ Specificity immunology
Immunity, Innate
Lymphocyte Subsets immunology
Neoplasms etiology
Subjects
Details
- Language :
- English
- ISSN :
- 2326-6074
- Volume :
- 6
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cancer immunology research
- Publication Type :
- Academic Journal
- Accession number :
- 29610422
- Full Text :
- https://doi.org/10.1158/2326-6066.CIR-17-0440