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Biophysical Properties of Extracellular Matrix: Linking Obesity and Cancer.

Authors :
Druso JE
Fischbach C
Source :
Trends in cancer [Trends Cancer] 2018 Apr; Vol. 4 (4), pp. 271-273. Date of Electronic Publication: 2018 Mar 10.
Publication Year :
2018

Abstract

Obesity has been associated with increased severity of diagnoses for several types of cancer, and recent evidence suggests that the mechanism by which obese tissues contribute to cancer progression involves the extracellular matrix (ECM). Understanding the physicochemical differences between lean and obese ECM, and how cancer cells respond to these differences, promises therapeutic insight.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)

Subjects

Subjects :
Adipokines metabolism
Adipose Tissue metabolism
Carcinogenesis metabolism
Carcinogenesis pathology
Disease Progression
Humans
Neoplasms metabolism
Adipose Tissue pathology
Biophysical Phenomena
Extracellular Matrix pathology
Neoplasms pathology
Obesity metabolism

Details

Language :
English
ISSN :
2405-8025
Volume :
4
Issue :
4
Database :
MEDLINE
Journal :
Trends in cancer
Publication Type :
Academic Journal
Accession number :
29606310
Full Text :
https://doi.org/10.1016/j.trecan.2018.02.001
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