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Single-Cell Transcriptomic Analysis of Tumor Heterogeneity.
- Source :
-
Trends in cancer [Trends Cancer] 2018 Apr; Vol. 4 (4), pp. 264-268. Date of Electronic Publication: 2018 Mar 09. - Publication Year :
- 2018
-
Abstract
- Intratumoral heterogeneity is among the greatest challenges in precision cancer therapy. However, developments in high-throughput single-cell RNA sequencing (scRNA-seq) may now provide the statistical power to dissect the diverse cellular populations of tumors. In the future these technologies might inform the selection of targeted combination therapies and enrollment criteria for clinical trials.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Combined Modality Therapy methods
Humans
Molecular Targeted Therapy methods
Neoplasms pathology
Neoplasms therapy
Precision Medicine methods
RNA genetics
Sequence Analysis, RNA
Computational Biology methods
Gene Expression Profiling methods
High-Throughput Nucleotide Sequencing
Neoplasms genetics
Single-Cell Analysis methods
Subjects
Details
- Language :
- English
- ISSN :
- 2405-8025
- Volume :
- 4
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Trends in cancer
- Publication Type :
- Academic Journal
- Accession number :
- 29606308
- Full Text :
- https://doi.org/10.1016/j.trecan.2018.02.003