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Numerical Imbalances of Chromosome 7 in Oral Squamous Cell Carcinoma.

Authors :: Mastronikolis NS
Tsiambas E
Fotiades PP
Baliou E
Karameris A
Peschos D
Mastronikolis SN
Asimakopoulos AD
Giannakopoulos X
Ragos V
Source :: Anticancer research [Anticancer Res] 2018 Apr; Vol. 38 (4), pp. 2339-2342.
Publication Year :: 2018
Abstract: Background: Oral squamous cell carcinoma (OSCC) is an aggressive neoplasm. Many chromosomal and gene alterations have been identified in OSCC, including structural and numerical changes. In this study, we implemented a molecular assay of chromosome 7 (Chr7) in order to investigate the level of its numerical instability in OSCC.<br />Materials and Methods: Using tissue microarray technology, 30 primary OSCCs were cored and re-embedded into one recipient block. Chromogenic in situ hybridization assay was performed based on Chr7 centromeric probedetection.<br />Results: Chr 7 numerical analysis detected polysomy (trisomy/ tetrasomy) in 4/30 (13.3%) of the examined tissue OSCC cores. Statistical significance was assessed correlating Chr7 numerical aberrations with stage (p=0.015), especially detected in cases not related to human papillomavirus (HPV) (p=0.01).<br />Conclusion: Although Chr7 polysomy is a relatively rare gross genetic event in OSSC, it affects their biological behavior leading toa progressively aggressive phenotype (advanced stage). Furthermore, Chr7 polysomy is observed more frequently in non-viral (HPV) cases.<br /> (Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)