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The antioxidant system in the soleus muscle of growing rats is stimulated by the administration of a low-protein/high-carbohydrate diet.
- Source :
-
Archives of physiology and biochemistry [Arch Physiol Biochem] 2019 Jul; Vol. 125 (3), pp. 276-283. Date of Electronic Publication: 2018 Mar 29. - Publication Year :
- 2019
-
Abstract
- The aim of this study was to evaluate the generation of reactive oxygen species (ROS) by xanthine oxidase (XO), the enzymatic antioxidant system and oxidative damage in soleus and extensor digitorum longus (EDL) muscles of growing rats fed a low-protein, high-carbohydrate (LPHC; 6% protein, 74% carbohydrate) diet for 15 days. The LPHC diet increased the total antioxidant capacity by 45% and the activities of glutathione peroxidase (GPx), glutathione reductase and catalase in the soleus muscles. There was an increase in the carbonylated proteins with no increase thiobarbituric acid reactive substances (TBARS), although the XO activity had increased 20%. In EDL muscles, the LPHC diet increased XO activity by 66% and the TBARS levels by 80%, and only GPx had its activity increased. These results suggest that the enzymatic antioxidant system of the soleus muscle has a better response to the increase of ROS production stimulated by LPHC diet.
- Subjects :
- Animals
Catalase metabolism
Glutathione metabolism
Glutathione Peroxidase metabolism
Glutathione Reductase metabolism
Male
Muscle, Skeletal drug effects
Muscle, Skeletal growth & development
Oxidative Stress drug effects
Protein Carbonylation
Rats
Rats, Wistar
Reactive Oxygen Species metabolism
Thiobarbituric Acid Reactive Substances metabolism
Antioxidants metabolism
Biomarkers analysis
Diet, Protein-Restricted
Dietary Carbohydrates
Muscle, Skeletal metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1744-4160
- Volume :
- 125
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Archives of physiology and biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 29595327
- Full Text :
- https://doi.org/10.1080/13813455.2018.1455709