Back to Search
Start Over
Hispanic Americans and Non-Hispanic White Americans Have a Similar Inflammatory Bowel Disease Phenotype: A Systematic Review with Meta-Analysis.
- Source :
-
Digestive diseases and sciences [Dig Dis Sci] 2018 Jun; Vol. 63 (6), pp. 1558-1571. Date of Electronic Publication: 2018 Mar 29. - Publication Year :
- 2018
-
Abstract
- Background: Inflammatory bowel disease (IBD) is a devastating immune-mediated disease on the rise in Hispanics living in the USA. Prior observational studies comparing IBD characteristics between Hispanics and non-Hispanic whites (NHW) have yielded mixed results.<br />Aims: We performed a meta-analysis of observational studies examining IBD phenotype in Hispanics compared to NHW.<br />Methods: We conducted a systematic search of US-based studies comparing IBD subtype (Ulcerative Colitis: UC or Crohn's disease: CD) and phenotype (disease location and behavior) between Hispanics and NHW. We evaluated differences in age at IBD diagnosis, the presence of family history and smoking history. A random effects model was chosen "a priori." Categorical and continuous variables were analyzed using odds ratio (OR) or standard mean difference (SMD), respectively.<br />Results: Seven studies were included with 687 Hispanics and 1586 NHW. UC was more common in Hispanics compared to NHW (OR 2.07, CI 1.13-3.79, p = 0.02). Location of disease was similar between Hispanics and NHW except for the presence of upper gastrointestinal CD, which was less common in Hispanics (OR 0.58, CI 0.32-1.06, p = 0.07). Hispanics were less likely to smoke (OR 0.48, CI 0.26-0.89, p = 0.02) or have a family history of IBD (OR 0.35, CI 0.22-0.55, p < 0.001). CD behavior classified by Montreal classification and age at IBD diagnosis were similar between Hispanics and NHW.<br />Conclusion: UC was more common among US Hispanics compared to NHW. Age at IBD diagnosis is similar for both Hispanics and NHW. For CD, disease behavior is similar, but Hispanics show a trend for less upper gastrointestinal involvement. A family history of IBD and smoking history were less common in Hispanics.
- Subjects :
- Age Factors
Colitis, Ulcerative diagnosis
Colitis, Ulcerative genetics
Crohn Disease diagnosis
Crohn Disease genetics
Genetic Predisposition to Disease
Humans
Observational Studies as Topic
Odds Ratio
Pedigree
Phenotype
Risk Factors
Smoking adverse effects
Smoking ethnology
United States epidemiology
Colitis, Ulcerative ethnology
Crohn Disease ethnology
Hispanic or Latino
White People
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2568
- Volume :
- 63
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Digestive diseases and sciences
- Publication Type :
- Academic Journal
- Accession number :
- 29594975
- Full Text :
- https://doi.org/10.1007/s10620-018-5022-7