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Sensitivity-Tunable Colorimetric Detection of Chloropicrin Vapor on Nylon-6 Nanofibrous Membrane Based on a Detoxification Reaction with Biological Thiols.
- Source :
-
ACS sensors [ACS Sens] 2018 Apr 27; Vol. 3 (4), pp. 858-866. Date of Electronic Publication: 2018 Apr 04. - Publication Year :
- 2018
-
Abstract
- Detoxification reaction of chloropicrin in the human body with biological thiols was selected for detection of chloropicrin in the air. The consumption of free sulfhydryl group in biological thiols by chloropicrin is colorimetrically detectable with the addition of the Ellman's reagent. In this study, glutathione, N-acetyl-l-cysteine, l-homocysteine, cysteamine, and thioglycolic acid were tested as sensing agents for chloropicrin vapor detection in ppb concentration range. The reactivity of the selected biological thiols was investigated based on both their redox properties and the nucleophilic strength of the sulfhydryl groups. Nylon-6 nanofibrous membrane and an organic solvent were used as a sensor matrix and a vapor sorbent, respectively, to provide solid supports with ultrahigh surface area and enhanced adsorption to chloropicrin vapor. The tunable sensitivity and detection range by using different biological thiols was achieved on the sensors due to the different reactivity of thiols toward chloropicrin.
- Subjects :
- Caprolactam chemistry
Caprolactam metabolism
Humans
Hydrocarbons, Chlorinated metabolism
Molecular Structure
Polymers metabolism
Sulfhydryl Compounds chemistry
Volatilization
Caprolactam analogs & derivatives
Colorimetry instrumentation
Hydrocarbons, Chlorinated analysis
Nanofibers chemistry
Polymers chemistry
Sulfhydryl Compounds metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2379-3694
- Volume :
- 3
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- ACS sensors
- Publication Type :
- Academic Journal
- Accession number :
- 29589433
- Full Text :
- https://doi.org/10.1021/acssensors.8b00135