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Sensitivity-Tunable Colorimetric Detection of Chloropicrin Vapor on Nylon-6 Nanofibrous Membrane Based on a Detoxification Reaction with Biological Thiols.

Authors :
Tang P
Leung HT
Gomez MT
Sun G
Source :
ACS sensors [ACS Sens] 2018 Apr 27; Vol. 3 (4), pp. 858-866. Date of Electronic Publication: 2018 Apr 04.
Publication Year :
2018

Abstract

Detoxification reaction of chloropicrin in the human body with biological thiols was selected for detection of chloropicrin in the air. The consumption of free sulfhydryl group in biological thiols by chloropicrin is colorimetrically detectable with the addition of the Ellman's reagent. In this study, glutathione, N-acetyl-l-cysteine, l-homocysteine, cysteamine, and thioglycolic acid were tested as sensing agents for chloropicrin vapor detection in ppb concentration range. The reactivity of the selected biological thiols was investigated based on both their redox properties and the nucleophilic strength of the sulfhydryl groups. Nylon-6 nanofibrous membrane and an organic solvent were used as a sensor matrix and a vapor sorbent, respectively, to provide solid supports with ultrahigh surface area and enhanced adsorption to chloropicrin vapor. The tunable sensitivity and detection range by using different biological thiols was achieved on the sensors due to the different reactivity of thiols toward chloropicrin.

Details

Language :
English
ISSN :
2379-3694
Volume :
3
Issue :
4
Database :
MEDLINE
Journal :
ACS sensors
Publication Type :
Academic Journal
Accession number :
29589433
Full Text :
https://doi.org/10.1021/acssensors.8b00135