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Urine and Serum Sex Steroid Profile in Testosterone-Treated Transgender and Hypogonadal and Healthy Control Men.
- Source :
-
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2018 Jun 01; Vol. 103 (6), pp. 2277-2283. - Publication Year :
- 2018
-
Abstract
- Background: The impact of testosterone (T) treatment on antidoping detection tests in female-to-male (F2M) transgender men is unknown. We investigated urine and serum sex steroid and luteinizing hormone (LH) profiles in T-treated F2M men to determine whether and, if so, how they differed from hypogonadal and healthy control men.<br />Method: Healthy transgender (n = 23) and hypogonadal (n = 24) men aged 18 to 50 years treated with 1000 mg injectable T undecanoate provided trough urine and blood samples and an additional earlier postinjection sample (n = 21). Healthy control men (n = 20) provided a single blood and urine sample. Steroids were measured by mass spectrometry-based methods in urine and serum, LH by immunoassay, and uridine 5'-diphospho-glucuronosyltransferase 2B17 genotype by polymerase chain reaction.<br />Results: Urine LH, human chorionic gonadotropin, T, epitestosterone (EpiT), androsterone (A), etiocholanolone (Etio), A/Etio ratio, dehydroepiandrosterone (DHEA), dihydrotestosterone (DHT), and 5α,3α- and 5β,3α-androstanediols did not differ between groups or by time since last T injection. Urine T/EpiT ratio was <4 in all controls and 12/68 (18%) samples from T-treated men, but there was no difference between T-treated groups. Serum estradiol, estrone, and DHEA were higher in transgender men, and serum T and DHT were higher in earlier compared with trough blood samples, but serum LH, follicle-stimulating hormone, and 3α- and 3β,5α-diols did not differ between groups.<br />Conclusion: Urine antidoping detection tests in T-treated transgender men can be interpreted like those of T-treated hypogonadal men and are unaffected by time since last T dose. Serum steroids are more sensitive to detect exogenous T administration early but not later after the last T dose.
- Subjects :
- Adolescent
Adult
Androgens blood
Androgens urine
Androsterone blood
Androsterone urine
Dehydroepiandrosterone blood
Dehydroepiandrosterone urine
Dihydrotestosterone blood
Dihydrotestosterone urine
Estradiol blood
Estradiol urine
Estrogens blood
Estrogens urine
Estrone blood
Estrone urine
Humans
Hypogonadism blood
Hypogonadism urine
Luteinizing Hormone blood
Luteinizing Hormone urine
Male
Mass Spectrometry
Middle Aged
Testosterone blood
Testosterone therapeutic use
Testosterone urine
Transgender Persons
Transsexualism blood
Transsexualism urine
Young Adult
Androgens metabolism
Estrogens metabolism
Hypogonadism drug therapy
Testosterone analogs & derivatives
Transsexualism drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1945-7197
- Volume :
- 103
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 29584875
- Full Text :
- https://doi.org/10.1210/jc.2018-00054