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Effects of short-term anti-inflammatory glucocorticoid treatment on clinicopathologic, echocardiographic, and hemodynamic variables in systemically healthy dogs.
- Source :
-
American journal of veterinary research [Am J Vet Res] 2018 Apr; Vol. 79 (4), pp. 411-423. - Publication Year :
- 2018
-
Abstract
- OBJECTIVE To investigate mechanisms by which anti-inflammatory doses of orally administered intermediate-acting glucocorticoids (prednisone) could predispose dogs to progression of heart disease or congestive heart failure. ANIMALS 11 client-owned dogs with allergic dermatitis and 11 matched healthy control dogs. PROCEDURES Clinicopathologic, echocardiographic, and hemodynamic variables were measured. Dogs with allergic dermatitis then received prednisone (1 mg/kg, PO) once daily for 14 consecutive days beginning on day 0 (baseline), followed by a tapering and washout period; control dogs received no treatment. Measurements were repeated on days 7, 14, and 35. Linear mixed modeling was used to compare changes in variables across measurement points and between dog groups. RESULTS Prednisone administration caused no significant changes in serum sodium or potassium concentration, blood glucose concentration, or target echocardiographic variables. The change from baseline in systolic arterial blood pressure at day 7 was significantly greater in prednisone-treated dogs than in control dogs. Expected changes in hematologic and serum biochemical values with prednisone administration (neutrophilia, eosinopenia, isosthenuria, and high serum alkaline phosphatase and alanine aminotransferase activities) also occurred in the prednisone-treated dogs. CONCLUSIONS AND CLINICAL RELEVANCE Findings suggested that anti-inflammatory doses of orally administered glucocorticoids have the potential to adversely impact cardiac function in dogs by causing an increase in blood pressure and thus increased cardiac afterload.
- Subjects :
- Animals
Anti-Inflammatory Agents therapeutic use
Dermatitis, Allergic Contact diet therapy
Dogs
Echocardiography drug effects
Echocardiography veterinary
Female
Glucocorticoids therapeutic use
Heart Diseases chemically induced
Heart Diseases veterinary
Heart Failure chemically induced
Heart Failure veterinary
Male
Potassium
Prednisone administration & dosage
Prednisone therapeutic use
Anti-Inflammatory Agents adverse effects
Blood Pressure drug effects
Dermatitis, Allergic Contact veterinary
Dog Diseases drug therapy
Glucocorticoids adverse effects
Hemodynamics drug effects
Prednisone adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1943-5681
- Volume :
- 79
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- American journal of veterinary research
- Publication Type :
- Academic Journal
- Accession number :
- 29583045
- Full Text :
- https://doi.org/10.2460/ajvr.79.4.411