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[PHYTOCORRECTION OF IMMUNOLOGICAL AND BIOCHEMICAL CHANGES IN THE COMBINED IMPACT OF COAL DUST AND HIGH DOSE OF RADIATION].
- Source :
-
Georgian medical news [Georgian Med News] 2018 Feb (Issue), pp. 141-150. - Publication Year :
- 2018
-
Abstract
- The objective of this researsh is to study the effects of Eminium Regelii phytopreparation (ERP) on immune status and free radical oxidation in the tissues of the adrenal glands and immunocompetent organs after combined exposure to 6 Gy dose of gamma irradiation and coal dust (remote period). The study was realized on 30 white laboratory male rats of the Wistar line, weighing 240±20g, that were divided into equal 3 groups: I group - intact, ІІ group - were exposured to combined effects of coal dust and gamma irradiation, III group - were exposured to combined effects and in parallel taking phytopreparation Eminium Regel. The animals of II and III groups were irradiated 90 days prior to the study at the TERAGAM 60Co radiotherapy unit ("ISOTREND spol. S.r.o.", Czech Republic) in dose of 6 Gy once. Experimental animals received phytopreparation of ER 2.5 mg/kg per day on calculate of body mass for 14 days. The results of the conducted studies showed that in the long-term period after the actions of the sublethal dose of gamma radiation and coal dust, significant changes were revealed that were characterized by a decrease in immunological reactivity, increased lipoperoxidation and inhibition of antioxidant defense activity of the organism. After exposure to ER, oxidative stress was alleviated, sufficient restoration of antioxidant protection and immune system indices, which were disrupted by the combined effects of a single high dose of radiation and a prolonged three-month inhalation of coal dust.
- Subjects :
- Adrenal Glands drug effects
Adrenal Glands immunology
Adrenal Glands radiation effects
Animals
Antigens, CD biosynthesis
Antigens, CD immunology
Antioxidants isolation & purification
B-Lymphocytes drug effects
B-Lymphocytes immunology
B-Lymphocytes radiation effects
Drug Administration Schedule
Dust analysis
Interferon-gamma biosynthesis
Interferon-gamma immunology
Interleukin-2 biosynthesis
Interleukin-2 immunology
Interleukin-6 biosynthesis
Interleukin-6 immunology
Lipid Peroxidation drug effects
Lipid Peroxidation radiation effects
Liver drug effects
Liver immunology
Liver radiation effects
Lymph Nodes drug effects
Lymph Nodes immunology
Lymph Nodes radiation effects
Male
Particulate Matter toxicity
Plant Extracts chemistry
Radiation-Protective Agents isolation & purification
Rats
Rats, Wistar
Spleen drug effects
Spleen immunology
Spleen radiation effects
T-Lymphocytes drug effects
T-Lymphocytes immunology
T-Lymphocytes radiation effects
Tumor Necrosis Factor-alpha biosynthesis
Tumor Necrosis Factor-alpha immunology
Antioxidants pharmacology
Araceae chemistry
Coal toxicity
Gamma Rays adverse effects
Particulate Matter antagonists & inhibitors
Radiation-Protective Agents pharmacology
Subjects
Details
- Language :
- Russian
- ISSN :
- 1512-0112
- Issue :
- Issue
- Database :
- MEDLINE
- Journal :
- Georgian medical news
- Publication Type :
- Academic Journal
- Accession number :
- 29578440