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Elevated high-sensitive troponin T in negative stress test individuals.

Authors :: Brzezinski RY
Fisher E
Ehrenwald M
Shefer G
Stern N
Shapira I
Zeltser D
Berliner S
Shenhar-Tsarfaty S
Milwidsky A
Rogowski O
Source :: European journal of clinical investigation [Eur J Clin Invest] 2018 Jun; Vol. 48 (6), pp. e12930. Date of Electronic Publication: 2018 Apr 16.
Publication Year :: 2018
Abstract: Background: The exercise ECG stress test (EST) is still the first step of work-up in intermediate risk patients in many clinical scenarios. High-sensitive cardiac troponin T (hs-cTnT) elevation is related to future cardiovascular events in the general population and in patients with ischaemic heart disease. The relation between these 2 tests is not well described.<br />Materials and Methods: A total of 2780 participants from the Tel-Aviv Medical Center Inflammation Survey cohort (mean age 49 years, 79% men) were analysed. Multiple physiologic and metabolic parameters including hs-cTnT were collected. All participants completed an EST manually reviewed by a cardiologist.<br />Results: A positive EST was documented in 224 subjects (8%). The majority (91%) of participants with hs-cTnT levels of 5-14 ng/L had a negative EST as well as 89.3% of subjects with levels >14 ng/L. The proportion of subjects with a positive EST and detectable hs-cTnT levels (>5 ng/L) was not significantly greater compared to those with a negative EST (53.1% vs 46.2%, respectively, P = .09).<br />Conclusion: Among subjects referred for EST as part of an annual health survey, we found no significant association between EST results to hs-cTnT detection.<br /> (© 2018 Stichting European Society for Clinical Investigation Journal Foundation.)