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Alcohol injection into the portal vein prior to ligation increases liver regeneration rate.
- Source :
-
HPB : the official journal of the International Hepato Pancreato Biliary Association [HPB (Oxford)] 2018 Aug; Vol. 20 (8), pp. 739-744. Date of Electronic Publication: 2018 Mar 20. - Publication Year :
- 2018
-
Abstract
- Background: Failure of portal vein ligation (PVL) to induce hypertrophy is not uncommon. The aim of the study was to evaluate the impact of intraportal alcohol injection prior to ligation on liver regeneration.<br />Method: Forty-two patients with colorectal liver metastases who underwent PVL between 01/2004 and 06/2014 were analyzed. Beginning in 09/2011, alcohol was injected prior to PVL. Patients treated with PVL alone (Alc- group) were compared with those treated with alcohol injection plus PVL (Alc+ group). Liver regeneration was assessed by volumetric increase (VI).<br />Results: Alc+ (23 patients) and Alc- (19 patients) groups were similar in terms of age, sex and pre-PVL FLRV. Alc- group had a higher risk of recanalization (12 vs. 1, p < 0.001) and cavernous transformation (7 vs. 2, p = 0.055) of the occluded portal vein. Post-PVL FLRV (43.3 ± 14.3% vs. 34.6 ± 6.4%, p = 0.013) and VI (0.44 ± 0.24 vs. 0.28 ± 0.20, p = 0.029) were higher in Alc+ group. On multivariate analysis male sex (B = -0.149) and alcohol injection (B = 0.143) significantly predicted VI.<br />Conclusions: Alcohol injection prior to PVL may increase the regeneration of the FLRV by reducing the recanalization of the occluded portal vein.<br /> (Copyright © 2018 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Cell Proliferation
Ethanol adverse effects
Female
Hepatectomy adverse effects
Humans
Injections, Intravenous
Ligation
Liver Circulation
Liver Neoplasms diagnostic imaging
Liver Neoplasms secondary
Male
Middle Aged
Portal Vein diagnostic imaging
Portal Vein physiopathology
Postoperative Complications etiology
Retrospective Studies
Time Factors
Tomography, X-Ray Computed
Treatment Outcome
Colorectal Neoplasms pathology
Ethanol administration & dosage
Hepatectomy methods
Liver Neoplasms blood supply
Liver Neoplasms surgery
Liver Regeneration
Portal Vein surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1477-2574
- Volume :
- 20
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- HPB : the official journal of the International Hepato Pancreato Biliary Association
- Publication Type :
- Academic Journal
- Accession number :
- 29571617
- Full Text :
- https://doi.org/10.1016/j.hpb.2018.02.637