Back to Search Start Over

Ruthenium(ii)-catalyzed olefination via carbonyl reductive cross-coupling.

Authors :
Wei W
Dai XJ
Wang H
Li C
Yang X
Li CJ
Source :
Chemical science [Chem Sci] 2017 Dec 01; Vol. 8 (12), pp. 8193-8197. Date of Electronic Publication: 2017 Oct 09.
Publication Year :
2017

Abstract

Natural availability of carbonyl groups offers reductive carbonyl coupling tremendous synthetic potential for efficient olefin synthesis, yet the catalytic carbonyl cross-coupling remains largely elusive. We report herein such a reaction, mediated by hydrazine under ruthenium(ii) catalysis. This method enables facile and selective cross-couplings of two unsymmetrical carbonyl compounds in either an intermolecular or intramolecular fashion. Moreover, this chemistry accommodates a variety of substrates, proceeds under mild reaction conditions with good functional group tolerance, and generates stoichiometric benign byproducts. Importantly, the coexistence of KO <superscript> t </superscript> Bu and bidentate phosphine dmpe is vital to this transformation.

Details

Language :
English
ISSN :
2041-6520
Volume :
8
Issue :
12
Database :
MEDLINE
Journal :
Chemical science
Publication Type :
Academic Journal
Accession number :
29568466
Full Text :
https://doi.org/10.1039/c7sc04207h