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Cisplatin concurrent chemoradiotherapy vs adjuvant radiation in stage IB/IIA cervical cancer with intermediate risk factors, treated with radical surgery: a retrospective study.
- Source :
-
OncoTargets and therapy [Onco Targets Ther] 2018 Mar 06; Vol. 11, pp. 1149-1155. Date of Electronic Publication: 2018 Mar 06 (Print Publication: 2018). - Publication Year :
- 2018
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Abstract
- Purpose: To determine if postoperative cisplatin concurrent chemoradiotherapy (CCRT) improves the outcome in stage IA/IIB cervical cancer patients with intermediate risk factors, when compared with radiation therapy (RT) alone, and identify the potential eligible populations for this treatment.<br />Patients and Methods: We reviewed medical records of 1,240 patients with stage IA/IIB cervical cancer who underwent radical hysterectomy and pelvic lymphadenectomy in our hospital between January 2008 and December 2011. Of the 1,240 patients, 436 displayed 1 or more intermediate risk factors. Of these, we screened 306 patients who underwent RT only or CCRT. We analyzed the effects of CCRT on survival and prognosis.<br />Results: The 5-year progress-free survival (PFS) in the CCRT group was superior to that in the RT-only group (96.0% vs 89.0%, respectively; P =0.031). The 5-year overall survivals (OSs) were not different between the 2 groups ( P =0.141). Compared with RT-only group, CCRT did not improve PFS or OS in patients with 1 risk factor, large tumor size, or deep stromal invasion ( P >0.05). Compared with RT-only group, CCRT improved PFS (97.9% vs 82.8%; P =0.017) but did not increase OS (97.9% vs 89.7%; P =0.109) in patients with lymphovascular space invasion plus deep stromal invasion/large tumor size. OS (92.3% vs 70.6%; P =0.048) and PFS (92.3% vs 64.7%; P =0.020) in the CCRT group were superior to those in the RT-only group with 3 risk factors. Compared with RT-only group, CCRT was an independent prognostic factor for favorable PFS (hazard ratio [HR] =0.238; 95% CI =0.0827-0.697, P =0.009) and OS (HR =0.192; 95% CI =0.069-0.533, P =0.002).<br />Conclusion: Postoperative CCRT improved survival in stage IA/IIB cervical cancer patients with intermediate risk factors. Patients with 2 or more intermediate risk factors, including lymphovascular space invasion, may benefit from CCRT.<br />Competing Interests: Disclosure The authors report no conflicts of interest in this work.
Details
- Language :
- English
- ISSN :
- 1178-6930
- Volume :
- 11
- Database :
- MEDLINE
- Journal :
- OncoTargets and therapy
- Publication Type :
- Academic Journal
- Accession number :
- 29563803
- Full Text :
- https://doi.org/10.2147/OTT.S158214