Back to Search
Start Over
Predictors of isoniazid preventive therapy completion among adults newly diagnosed with HIV in rural Malawi.
- Source :
-
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [Int J Tuberc Lung Dis] 2018 Apr 01; Vol. 22 (4), pp. 371-377. - Publication Year :
- 2018
-
Abstract
- Setting: To reduce the risk of tuberculosis (TB) among individuals with human immunodeficiency virus (HIV) infection, the World Health Organization recommends at least 6 months of isoniazid preventive therapy (IPT). Completion of IPT remains a major challenge in resource-limited settings.<br />Objective: To evaluate predictors of IPT completion in individuals newly diagnosed with HIV.<br />Design: Predictors of IPT completion among adults newly diagnosed with HIV in rural Malawi were evaluated using a multilevel logistic regression model.<br />Results: Of 974 participants who screened negative for active TB and were started on IPT, 732 (75%) completed treatment. Only one IPT-eligible individual refused treatment. Participants who were aged <25 years (compared with those aged 45 years, adjusted OR [aOR] 0.33, 95%CI 0.18-0.60) and male (compared to non-pregnant females, aOR 0.57, 95%CI 0.37-0.88) had lower odds of IPT completion.<br />Conclusion: IPT provision at the time of initial HIV diagnosis was highly acceptable in rural Malawi; three quarters of those who initiated IPT successfully completed therapy. We observed lower odds of completion among males and among female participants aged <25 years. Additional efforts may be needed to ensure IPT completion among males and young females who have recently been diagnosed with HIV.
- Subjects :
- Adolescent
Adult
Female
Humans
Kaplan-Meier Estimate
Logistic Models
Malawi
Male
Middle Aged
Pregnancy
Pregnancy Rate
Risk Factors
Rural Population
Young Adult
Antitubercular Agents therapeutic use
HIV Infections complications
Isoniazid therapeutic use
Medication Adherence statistics & numerical data
Tuberculosis prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1815-7920
- Volume :
- 22
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
- Publication Type :
- Academic Journal
- Accession number :
- 29562983
- Full Text :
- https://doi.org/10.5588/ijtld.16.0836