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Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo.
- Source :
-
Marine drugs [Mar Drugs] 2018 Mar 21; Vol. 16 (4). Date of Electronic Publication: 2018 Mar 21. - Publication Year :
- 2018
-
Abstract
- Soft corals are known to be prolific producers of a wide spectrum of biologically active cembranoids. One new cembranoid, sinularolide F ( 2 ), along with three known compounds, cembranolide ( 1 ), ( E , E , E )-6,10,14-trimethyl-3-methylene- cis -3α,4,5,8,9,12,13,15α-octahydrocyclo tetradeca[β]furan-2( 3H )-one ( 3 ), and denticulatolide ( 4 ), were isolated from the Bornean soft coral Sinularia sp. Compounds 2 and 4 showed potential anti-inflammatory activities against lipopolysaccharide-stimulated RAW 264.7 with IC <subscript>50</subscript> values less than 6.25 µg/mL and anticancer activity against HL60 cell lines. The compounds' mechanisms of action were investigated via the Western blot evaluation of their protein markers. These activities could be attributed to the presence of tertiary methyl at C-8 and the compounds' 3D configurations.<br />Competing Interests: The authors declare no conflict of interest. The funding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.
Details
- Language :
- English
- ISSN :
- 1660-3397
- Volume :
- 16
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Marine drugs
- Publication Type :
- Academic Journal
- Accession number :
- 29561805
- Full Text :
- https://doi.org/10.3390/md16040099