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Association of non-invasive hemodynamics with arterial stiffness in rheumatoid arthritis.
- Source :
-
Scandinavian cardiovascular journal : SCJ [Scand Cardiovasc J] 2018 Aug; Vol. 52 (4), pp. 171-176. Date of Electronic Publication: 2018 Mar 21. - Publication Year :
- 2018
-
Abstract
- Objectives: Arterial stiffness has emerged as a surrogate marker of cardiovascular disease. We investigated the role of myocardial performance and hemodynamic parameters in arterial stiffness in patients with rheumatoid arthritis (RA), which is accompanied by excess cardiovascular risk.<br />Design: Arterial stiffness was evaluated with pulse wave velocity (PWV) in RA patients and controls. Cardiac and hemodynamic characterization was based on impedance cardiography. Cardiovascular risk factors, inflammatory markers and disease-related parameters were assessed.<br />Results: PWV (8.2 ± 2.1 vs 7.4 ± 1.4 m/s, p = .016) was higher among RA patients (n = 104) compared to controls (n = 52). In the RA group, PWV correlated with markers of cardiac contractibility (acceleration and velocity index), myocardial blood flow (cardiac output and stroke volume), preload (thoracic fluid content) and afterload (systemic vascular resistance) (p < .05 for all). PWV tended to increase with decreasing oxygen delivery to the myocardium (r = 0.055), as well as with shortening of the ejection duration of the left ventricle (p = .058). However, these associations no longer remained significant after adjustment for classical cardiovascular risk factors, inflammation and corticosteroid use, which were independently associated with PWV.<br />Conclusions: Among patients with RA, arterial stiffness appears as the composite of cardiovascular risk factors and inflammation, while corticosteroid use emerges as an additional adverse factor.
- Subjects :
- Adrenal Cortex Hormones adverse effects
Aged
Arthritis, Rheumatoid diagnosis
Arthritis, Rheumatoid drug therapy
Arthritis, Rheumatoid physiopathology
Cardiography, Impedance
Cardiovascular Diseases diagnosis
Cardiovascular Diseases physiopathology
Case-Control Studies
Chi-Square Distribution
Female
Humans
Inflammation Mediators blood
Linear Models
Male
Middle Aged
Multivariate Analysis
Myocardial Contraction
Pulse Wave Analysis
Risk Factors
Stroke Volume
Ventricular Function, Left
Arthritis, Rheumatoid complications
Cardiovascular Diseases etiology
Hemodynamics
Vascular Stiffness
Subjects
Details
- Language :
- English
- ISSN :
- 1651-2006
- Volume :
- 52
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Scandinavian cardiovascular journal : SCJ
- Publication Type :
- Academic Journal
- Accession number :
- 29560750
- Full Text :
- https://doi.org/10.1080/14017431.2018.1453943