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Effect of SSRI and calcium channel blockers on depression symptoms and cognitive function in elderly persons treated for hypertension: three city cohort study.
- Source :
-
International psychogeriatrics [Int Psychogeriatr] 2018 Sep; Vol. 30 (9), pp. 1345-1354. Date of Electronic Publication: 2018 Mar 21. - Publication Year :
- 2018
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Abstract
- ABSTRACTBackground:Emerging genetic, ex-vivo, and clinical trial evidence indicates that calcium channel blockers (CCB) can improve mood and cognitive function. The objective of this study was to examine the effect of selective serotonin reuptake inhibitor (SSRI) therapy augmented with CCB on depression and cognitive decline in an elderly population with hypertension.<br />Methods: Prospective study of 296 persons treated with SSRI and antihypertensive drugs. Baseline and two year clinic assessments were used to categorize participants as users of SSRI + CCB (n = 53) or users of SSRI + other antihypertensives (n = 243). Clinic visits were performed up to four times in a ten-year period to assess depression and cognitive function.<br />Results: The sample mean age was 75.2 ± 5.47 years and 78% of participants were female. At two year follow-up there was a significant group by time interaction showing lower Center for Epidemiological Studies-Depression (CESD) scores in the SSRI + CCB group, F(1,291) = 4.13, p = 0.043, η2p = 0.014. Over ten-years follow-up, SSRI + CCB use was associated with improved general cognitive function (Mini-Mental State Examination: β = 0.97; 95% CI 0.14 to 1.81, p = 0.023) and immediate visual memory (Boston Visual Retention Test: β = 0.69; 95% CI 0.06 to 1.32, p = 0.033).<br />Conclusion: The findings provide general population evidence that SSRI augmentation with CCB may improve depression and cognitive function.
- Subjects :
- Affect drug effects
Aged
Aged, 80 and over
Cognition drug effects
Cognitive Dysfunction complications
Depression complications
Female
France
Humans
Hypertension complications
Logistic Models
Male
Memory drug effects
Mental Status and Dementia Tests
Prospective Studies
Treatment Outcome
Calcium Channel Blockers therapeutic use
Cognitive Dysfunction drug therapy
Depression drug therapy
Hypertension drug therapy
Selective Serotonin Reuptake Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1741-203X
- Volume :
- 30
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- International psychogeriatrics
- Publication Type :
- Academic Journal
- Accession number :
- 29559030
- Full Text :
- https://doi.org/10.1017/S1041610217002903