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Protein C deficiency in splanchnic venous thrombosis.
- Source :
-
The American journal of medicine [Am J Med] 1987 Jun; Vol. 82 (6), pp. 1171-4. - Publication Year :
- 1987
-
Abstract
- Deficiencies of protein C activity and antigen were observed in eight consecutive patients with splanchnic venous thrombosis. There was a significant reduction in the ratio of protein C to factor X. Six of the eight patients had a decrease in antithrombin III, but free protein S antigen was within normal limits in all but two subjects. It is proposed that a thrombogenic stimulus such as stasis, altered hormonal milieu, or failure of hepatic clearance of activated coagulants results in consumption of protein C and antithrombin III, predisposing to splanchnic venous occlusion. This further impairs hepatic function, prevents restitution of protein C and antithrombin levels, and promotes continuing venous thrombosis. Thus, a vicious cycle of thrombosis and hepatic damage is perpetuated.
Details
- Language :
- English
- ISSN :
- 0002-9343
- Volume :
- 82
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The American journal of medicine
- Publication Type :
- Academic Journal
- Accession number :
- 2955698
- Full Text :
- https://doi.org/10.1016/0002-9343(87)90220-8