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Blend of organic acids and medium chain fatty acids prevents the inflammatory response and intestinal barrier dysfunction in mice challenged with enterohemorrhagic Escherichia coli O157:H7.
- Source :
-
International immunopharmacology [Int Immunopharmacol] 2018 May; Vol. 58, pp. 64-71. Date of Electronic Publication: 2018 Mar 16. - Publication Year :
- 2018
-
Abstract
- Impaired epithelial barrier function disrupts immune homeostasis and increases inflammation in intestines, leading to many intestinal diseases. The blend of organic acids (OAs) and medium chain fatty acids (MCFAs) has been shown to have synergistic bactericidal effect. In this study, we demonstrated that two blends of OAs and MCFAs (OM1 and OM2) could prevent the inflammatory response and intestinal barrier dysfunction in enterohemorrhagic Escherichia coli (EHEC)-infected mice. Treatments of OM1 and OM2 significantly reduced the body weight loss and production of IL-6 and TNF-α induced by EHEC. Mice treated with OM1 and OM2 showed decrease in serum D-lactic concentration, DAO activity and bacterial transfer to liver and spleen. Furthermore, OM1 and OM2 increased the expression of tight junction proteins occludin and ZO-1, mucus protein MUC-2, and host defense peptides mBD1, mBD2 and mBD3. Finally, OM1 and OM2 increased the population of Lactobacillus spp. and Bifidobacterium spp., but decreased that of E. coli in the cecum. These findings indicate that OM1 and OM2 may be used to develop a prophylactic agent for intestinal inflammation and injury in enteric pathogen infection.<br /> (Copyright © 2018. Published by Elsevier B.V.)
- Subjects :
- Acids chemistry
Animals
Cecum microbiology
Cecum physiology
Complex Mixtures chemistry
D-Amino-Acid Oxidase metabolism
Escherichia coli Infections immunology
Fatty Acids chemistry
Female
Inflammation immunology
Interleukin-6 metabolism
Intestinal Mucosa drug effects
Intestinal Mucosa pathology
Lactic Acid blood
Mice
Mice, Inbred C57BL
Permeability drug effects
Tight Junctions metabolism
Tumor Necrosis Factor-alpha metabolism
Acids therapeutic use
Complex Mixtures therapeutic use
Escherichia coli Infections drug therapy
Escherichia coli O157 physiology
Fatty Acids therapeutic use
Inflammation drug therapy
Intestinal Mucosa metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1705
- Volume :
- 58
- Database :
- MEDLINE
- Journal :
- International immunopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 29555328
- Full Text :
- https://doi.org/10.1016/j.intimp.2018.03.014