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Cognitive Impairment and Structural Abnormalities in Late Life Depression with Olfactory Identification Impairment: an Alzheimer's Disease-Like Pattern.
- Source :
-
The international journal of neuropsychopharmacology [Int J Neuropsychopharmacol] 2018 Jul 01; Vol. 21 (7), pp. 640-648. - Publication Year :
- 2018
-
Abstract
- Background: Late-life depression patients are at a high risk of developing Alzheimer's disease, and diminished olfactory identification is an indicator in early screening for Alzheimer's disease in the elderly. However, whether diminished olfactory identification is associated with risk of developing Alzheimer's disease in late-life depression patients remains unclear.<br />Methods: One hundred and twenty-five late-life depression patients, 50 Alzheimer's disease patients, and 60 normal controls were continuously recruited. The participants underwent a clinical evaluation, olfactory test, neuropsychological assessment, and neuroimaging assessment.<br />Results: The olfactory identification impairment in late-life depression patients was milder than that in Alzheimer's disease patients. Diminished olfactory identification was significantly correlated with worse cognitive performance (global function, memory language, executive function, and attention) and reduced grey matter volume (olfactory bulb and hippocampus) in the late-life depression patients. According to a multiple linear regression analysis, olfactory identification was significantly associated with the memory scores in late-life depression group (B=1.623, P<.001). The late-life depression with olfactory identification impairment group had worse cognitive performance (global, memory, language, and executive function) and more structural abnormalities in Alzheimer's disease-related regions than the late-life depression without olfactory identification impairment group, and global cognitive function and logical memory in the late-life depression without olfactory identification impairment group was intact. Reduced volume observed in many areas (hippocampus, precuneus, etc.) in the Alzheimer's disease group was also observed in late-life depression with olfactory identification impairment group but not in the late-life depression without olfactory identification impairment group.<br />Conclusion: The patterns of cognitive impairment and structural abnormalities in late-life depression with olfactory identification impairment patients were similar to those in Alzheimer's disease; olfactory identification may help identify late-life depression patients who are at a high risk of developing Alzheimer's disease.
- Subjects :
- Aged
Aged, 80 and over
Female
Gray Matter diagnostic imaging
Humans
Male
Middle Aged
Aging pathology
Aging physiology
Alzheimer Disease diagnostic imaging
Alzheimer Disease pathology
Alzheimer Disease physiopathology
Cognitive Dysfunction diagnostic imaging
Cognitive Dysfunction pathology
Cognitive Dysfunction physiopathology
Depressive Disorder diagnostic imaging
Depressive Disorder pathology
Depressive Disorder physiopathology
Gray Matter pathology
Olfaction Disorders diagnostic imaging
Olfaction Disorders pathology
Olfaction Disorders physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1469-5111
- Volume :
- 21
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The international journal of neuropsychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 29554341
- Full Text :
- https://doi.org/10.1093/ijnp/pyy016