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Linear assembly of a human centromere on the Y chromosome.
- Source :
-
Nature biotechnology [Nat Biotechnol] 2018 Apr; Vol. 36 (4), pp. 321-323. Date of Electronic Publication: 2018 Mar 19. - Publication Year :
- 2018
-
Abstract
- The human genome reference sequence remains incomplete owing to the challenge of assembling long tracts of near-identical tandem repeats in centromeres. We implemented a nanopore sequencing strategy to generate high-quality reads that span hundreds of kilobases of highly repetitive DNA in a human Y chromosome centromere. Combining these data with short-read variant validation, we assembled and characterized the centromeric region of a human Y chromosome.
Details
- Language :
- English
- ISSN :
- 1546-1696
- Volume :
- 36
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Nature biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 29553574
- Full Text :
- https://doi.org/10.1038/nbt.4109