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The BDNF Val66Met polymorphism moderates the relationship between Posttraumatic Stress Disorder and fear extinction learning.
- Source :
-
Psychoneuroendocrinology [Psychoneuroendocrinology] 2018 May; Vol. 91, pp. 142-148. Date of Electronic Publication: 2018 Mar 06. - Publication Year :
- 2018
-
Abstract
- The low expression Met allele of the BDNF Val66Met polymorphism is associated with impaired fear extinction in healthy controls, and poorer response to exposure therapy in patients with Posttraumatic Stress Disorder (PTSD). Given that fear extinction underlies exposure therapy, this raises the question of the impact of BDNFVal66Met polymorphism on fear extinction in PTSD, yet this question has not yet been examined. One hundred and six participants (22 PTSD, 46 trauma-exposed controls (TC) and 38 non-trauma exposed controls (NTC)) completed a fear conditioning and extinction task and saliva samples were taken for DNA extraction and genotyped for the BDNF Val66Met polymorphism. Moderation analyses using PROCESS examined whether BDNF genotype (Val-Val vs Met carriers) moderated the relationship between PTSD symptom severity (and diagnostic status) and skin conductance response (SCR) amplitude during fear extinction. The PTSD group displayed significantly slower fear extinction learning compared to TC and NTC in the early extinction phase. The BDNF Val66Met polymorphism moderated the relationship between PTSD and fear extinction learning, such that poorer fear extinction learning was associated with greater PTSD symptom severity (and PTSD diagnostic status) in individuals with the low-expression Met allele, but no relationship was demonstrated in individuals with the Val-Val allele. This study reveals that impaired fear extinction learning is particularly evident in individuals with PTSD who carry the low-expression BDNF Met allele and importantly not in those with the Val-Val allele. This provides novel evidence of a link between BDNF and impaired fear extinction learning in PTSD, which may contribute to poorer response to exposure therapy.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Alleles
Brain-Derived Neurotrophic Factor metabolism
Fear psychology
Female
Humans
Implosive Therapy methods
Learning physiology
Male
Middle Aged
Polymorphism, Single Nucleotide genetics
Stress Disorders, Post-Traumatic metabolism
Brain-Derived Neurotrophic Factor genetics
Extinction, Psychological physiology
Stress Disorders, Post-Traumatic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3360
- Volume :
- 91
- Database :
- MEDLINE
- Journal :
- Psychoneuroendocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 29550677
- Full Text :
- https://doi.org/10.1016/j.psyneuen.2018.03.002