Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms: Opportunities in cancer therapeutics.

Authors :: Cardama GA
Alonso DF
Gonzalez N
Maggio J
Gomez DE
Rolfo C
Menna PL
Source :: Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2018 Apr; Vol. 124, pp. 29-36. Date of Electronic Publication: 2018 Feb 04.
Publication Year :: 2018
Abstract: Rac1 GTPase signaling pathway has a critical role in the regulation of a plethora of cellular functions governing cancer cell behavior. Recently, it has been shown a critical role of Rac1 in the emergence of resistance mechanisms to cancer therapy. This review describes the current knowledge regarding Rac1 pathway deregulation and its association with chemoresistance, radioresistance, resistance to targeted therapies and immune evasion. This supports the idea that interfering Rac1 signaling pathway could be an interesting approach to tackle cancer resistance.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)

Subjects :: Animals
Humans
Molecular Targeted Therapy
Neoplasms genetics
Signal Transduction genetics
Tumor Escape genetics
Drug Resistance, Neoplasm genetics
Neoplasms drug therapy
Neoplasms radiotherapy
Radiation Tolerance genetics
rac1 GTP-Binding Protein physiology

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