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Ceramide stearic to palmitic acid ratio predicts incident diabetes.
- Source :
-
Diabetologia [Diabetologia] 2018 Jun; Vol. 61 (6), pp. 1424-1434. Date of Electronic Publication: 2018 Mar 15. - Publication Year :
- 2018
-
Abstract
- Aims/hypothesis: Ceramide lipids have a role in the development of insulin resistance, diabetes and risk of cardiovascular disease. Here we investigated four ceramides and their ratios to find the best predictors of incident diabetes.<br />Methods: A validated mass-spectrometric method was applied to measure Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:0) and Cer(d18:1/24:1) from serum or plasma samples. These ceramides were analysed in a population-based risk factor study (FINRISK 2002, n = 8045), in a cohort of participants undergoing elective coronary angiography for suspected stable angina pectoris (Western Norway Coronary Angiography Cohort [WECAC], n = 3344) and in an intervention trial investigating improved methods of lifestyle modification for individuals at high risk of the metabolic syndrome (Prevent Metabolic Syndrome [PrevMetSyn], n = 371). Diabetes risk score models were developed to estimate the 10 year risk of incident diabetes.<br />Results: Analysis in FINRISK 2002 showed that the Cer(d18:1/18:0)/Cer(d18:1/16:0) ceramide ratio was predictive of incident diabetes (HR per SD 2.23, 95% CI 2.05, 2.42), and remained significant after adjustment for several risk factors, including BMI, fasting glucose and HbA <subscript>1c</subscript> (HR 1.34, 95% CI 1.14, 1.57). The finding was validated in the WECAC study (unadjusted HR 1.81, 95% CI 1.53, 2.14; adjusted HR 1.39, 95% CI 1.16, 1.66). In the intervention trial, the ceramide ratio and diabetes risk scores significantly decreased in individuals who had 5% or more weight loss.<br />Conclusions/interpretation: The Cer(d18:1/18:0)/Cer(d18:1/16:0) ratio is an independent predictive biomarker for incident diabetes, and may be modulated by lifestyle intervention.
- Subjects :
- Aged
Angina Pectoris complications
Angina Pectoris diagnosis
Body Mass Index
Cohort Studies
Coronary Angiography
Diabetes Mellitus blood
Female
Finland
Humans
Insulin Resistance
Male
Mass Spectrometry
Metabolic Syndrome metabolism
Norway
Risk Factors
Weight Loss
Ceramides blood
Diabetes Mellitus diagnosis
Palmitic Acid blood
Stearic Acids blood
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0428
- Volume :
- 61
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Diabetologia
- Publication Type :
- Academic Journal
- Accession number :
- 29546476
- Full Text :
- https://doi.org/10.1007/s00125-018-4590-6