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Umezawamides, new bioactive polycyclic tetramate macrolactams isolated from a combined-culture of Umezawaea sp. and mycolic acid-containing bacterium.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 2018 Jul; Vol. 71 (7), pp. 653-657. Date of Electronic Publication: 2018 Mar 14. - Publication Year :
- 2018
-
Abstract
- New polycyclic tetramate macrolactams, Umezawamides A (1) and B (2) were isolated from a combined-culture of Umezawaea sp. RD066910 and mycolic-acid containing bacterium Tsukamurella pulmonis TP-B0596. Their planar structures and partial stereochemistries were determined based on the spectroscopic analysis, MMFF conformational search, and ECD calculations. Umezawamides are the first secondary metabolites isolated from the genus Umezawaea and they exhibited cytotoxicities to P388 murine leukemia cells. Furthermore, umezawamide A (1) showed growth inhibitory activity against Candida albicans.
- Subjects :
- Animals
Anti-Bacterial Agents pharmacology
Antibiotics, Antineoplastic chemistry
Antibiotics, Antineoplastic isolation & purification
Antibiotics, Antineoplastic pharmacology
Antifungal Agents chemistry
Antifungal Agents isolation & purification
Antifungal Agents pharmacology
Bacteria drug effects
Candida albicans drug effects
Cell Line, Tumor
Humans
Leukemia P388 drug therapy
Mice
Microbial Sensitivity Tests
Molecular Conformation
Actinomycetales chemistry
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents isolation & purification
Lactams, Macrocyclic isolation & purification
Lactams, Macrocyclic pharmacology
Mycolic Acids metabolism
Polycyclic Compounds isolation & purification
Polycyclic Compounds pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1881-1469
- Volume :
- 71
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 29540776
- Full Text :
- https://doi.org/10.1038/s41429-018-0040-4