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Neutrophil CD64 expression, procalcitonin and presepsin are useful to differentiate infections from flares in SLE patients with SIRS.
- Source :
-
Lupus [Lupus] 2018 Jun; Vol. 27 (7), pp. 1130-1139. Date of Electronic Publication: 2018 Mar 14. - Publication Year :
- 2018
-
Abstract
- Background/Objective Differentiating systemic lupus erythematosus (SLE) activity from infections in febrile patients is difficult because of similar initial clinical presentation. The aim of this study is to evaluate the usefulness of a number of biomarkers for differentiating infections from activity in SLE patients admitted with systemic inflammatory response (SIRS). Methods Patients with SLE and SIRS admitted to the emergency room were included in this study. Measurements of different markers including procalcitonin, neutrophil CD64 expression and presepsin, were performed. Infection was considered present when positive cultures and/or polymerase chain reaction were obtained. Sensitivity and specificity were calculated for all biomarkers. Results Twenty-seven patients were admitted, 23 women (82.5%), mean age 33.2 years. An infectious disease was confirmed in 12 cases. Markers for SLE activity including anti-DNA titers by IIF ( p = 0.041) and enzyme-linked immunosorbent assay ( p = 0.009) were used for differentiating SLE flares from infection. On the contrary, increased procalcitonin ( p = 0.047), neutrophil CD64 expression by flow cytometry ( p = 0.037) and presepsin ( p = 0.037) levels were observed in infected SLE patients. Conclusions High neutrophil CD64 expression, presepsin and procalcitonin levels are useful to differentiate infections from activity in SLE patients. In most cases, a positive bioscore that includes these three markers demonstrate the presence of an infectious disease.
- Subjects :
- Adult
Biomarkers blood
Cross-Sectional Studies
Diagnosis, Differential
Female
Fever blood
Humans
Immunosuppressive Agents therapeutic use
Infections blood
Lupus Erythematosus, Systemic blood
Male
Middle Aged
Calcitonin blood
Fever diagnosis
Infections diagnosis
Lipopolysaccharide Receptors blood
Lupus Erythematosus, Systemic complications
Neutrophils chemistry
Peptide Fragments blood
Receptors, IgG blood
Systemic Inflammatory Response Syndrome blood
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0962
- Volume :
- 27
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Lupus
- Publication Type :
- Academic Journal
- Accession number :
- 29540108
- Full Text :
- https://doi.org/10.1177/0961203318763740