Back to Search
Start Over
Association of circulating ANGPTL 3, 4, and 8 levels with medical status in a population undergoing routine medical checkups: A cross-sectional study.
- Source :
-
PloS one [PLoS One] 2018 Mar 14; Vol. 13 (3), pp. e0193731. Date of Electronic Publication: 2018 Mar 14 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- Purpose: Angiopoietin-like proteins (ANGPTLs) 3, 4, and 8 reportedly contribute to progression of metabolic disease, a risk factor for cardiovascular disease (CVD). The purpose of this study was to investigate whether circulating ANGPTL levels are associated with CVD risk after adjustment for potential confounding factors.<br />Methods: We conducted a single center, cross-sectional study of 988 Japanese subjects undergoing routine health checks. Serum ANGPTL3, 4, and 8 levels were measured using an enzyme-linked immunosorbent assay. Using multiple regression analysis we evaluated potential association of circulating ANGPTL3, 4, and 8 levels with general medical status including age, sex, smoking, drinking, obesity, hypertension, impaired glycometabolism, dyslipidemia, hyperuricemia, hepatic impairment, chronic kidney disease, anemia, cardiac abnormality, and inflammation.<br />Results: Circulating ANGPTL3 levels were relatively high in health-related categories of hepatic impairment and inflammation. Circulating ANGPTL4 levels were also significantly high in impaired glycometabolism or hepatic impairment but decreased in inflammation. Finally, increased ANGPTL8 levels were observed in obesity, impaired glycometabolism and dyslipidemia. Particularly, increased levels of circulating ANGPTL8 were positively correlated with circulating triglycerides and LDL-cholesterol levels and inversely correlated with circulating HDL-cholesterol levels.<br />Conclusions: Circulating ANGPTL3, 4, and 8 levels reflect some risk factors for CVD development.
- Subjects :
- Adult
Age Factors
Aged
Alcohol Drinking
Angiopoietin-Like Protein 3
Angiopoietin-Like Protein 8
Cardiovascular Diseases blood
Cholesterol, HDL blood
Cholesterol, LDL blood
Cross-Sectional Studies
Dyslipidemias blood
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Middle Aged
Obesity blood
Regression Analysis
Risk Factors
Sex Factors
Smoking
Triglycerides blood
Angiopoietin-Like Protein 4 blood
Angiopoietin-like Proteins blood
Cardiovascular Diseases pathology
Dyslipidemias pathology
Obesity pathology
Peptide Hormones blood
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 13
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 29538435
- Full Text :
- https://doi.org/10.1371/journal.pone.0193731