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Susceptibility profile of echinocandins, azoles and amphotericin B against yeast phase of Talaromyces marneffei isolated from HIV-infected patients in Guangdong, China.
- Source :
-
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2018 Jun; Vol. 37 (6), pp. 1099-1102. Date of Electronic Publication: 2018 Mar 13. - Publication Year :
- 2018
-
Abstract
- Talaromyces marneffei (T. marneffei) can cause talaromycosis, a fatal systemic mycosis, in patients with AIDS. With the increasing number of talaromycosis cases in Guangdong, China, we aimed to investigate the susceptibility of 189 T. marneffei clinical strains to eight antifungal agents, including three echinocandins (anidulafungin, micafungin, and caspofungin), four azoles (posaconazole, itraconazole, voriconazole, and fluconazole), and amphotericin B, with determining minimal inhibition concentrations (MIC) by Sensititre YeastOne™ YO10 assay in the yeast phase. The MICs of anidulafungin, micafungin, caspofungin, posaconazole, itraconazole, voriconazole, fluconazole, and amphotericin B were 2 to > 8 μg/ml, >8 μg/ml, 2 to > 8 μg/ml, ≤ 0.008 to 0.06 μg/ml, ≤ 0.015 to 0.03 μg/ml, ≤ 0.008 to 0.06 μg/ml, 1 to 32 μg/ml, and ≤ 0.12 to 1 μg/ml, respectively. The MICs of all echinocandins were very high, while the MICs of posaconazole, itraconazole, and voriconazole, as well as amphotericin B were comparatively low. Notably, fluconazole was found to have a higher MIC than other azoles, and exhibited particularly weak activity against some isolates with MICs over 8 μg/ml. Our data in vitro support the use of amphotericin B, itraconazole, voriconazole, and posaconazole in management of talaromycosis and suggest potential resistance to fluconazole.
- Subjects :
- Anidulafungin
HIV Infections complications
Humans
Lipopeptides pharmacology
Micafungin
Microbial Sensitivity Tests
Mycoses drug therapy
Mycoses microbiology
Reagent Kits, Diagnostic
Talaromyces isolation & purification
Talaromyces physiology
Voriconazole pharmacology
Amphotericin B pharmacology
Antifungal Agents pharmacology
Azoles pharmacology
Echinocandins pharmacology
HIV Infections microbiology
Talaromyces drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1435-4373
- Volume :
- 37
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 29536323
- Full Text :
- https://doi.org/10.1007/s10096-018-3222-x