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A three-generation study on the association of tobacco smoking with asthma.
- Source :
-
International journal of epidemiology [Int J Epidemiol] 2018 Aug 01; Vol. 47 (4), pp. 1106-1117. - Publication Year :
- 2018
-
Abstract
- Background: Mothers' smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers' smoking may have a similar effect, and biological plausibility that fathers' smoking during adolescence may influence offspring's health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma.<br />Methods: Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents' (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines.<br />Results: Fathers' smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01-2.01] and mothers' smoking during pregnancy (RRR = 1.27, 95% CI: 1.01-1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers' smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17-2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02-1.55).<br />Conclusions: Fathers' smoking during early adolescence and grandmothers' and mothers' smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception.<br />Funding: European Union (Horizon 2020, GA-633212).
- Subjects :
- Adolescent
Adult
Aged
Australia epidemiology
Child
Child, Preschool
Europe epidemiology
Female
Health Surveys
Humans
Infant
Infant, Newborn
Male
Middle Aged
Multilevel Analysis
Pregnancy
Prenatal Exposure Delayed Effects
Regression Analysis
Risk Factors
Young Adult
Asthma epidemiology
Grandparents
Parents
Tobacco Smoking epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3685
- Volume :
- 47
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 29534228
- Full Text :
- https://doi.org/10.1093/ije/dyy031