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Hypervirulence and biofilm production in KPC-2-producing Klebsiella pneumoniae CG258 isolated in Brazil.
- Source :
-
Journal of medical microbiology [J Med Microbiol] 2018 Apr; Vol. 67 (4), pp. 523-528. Date of Electronic Publication: 2018 Mar 06. - Publication Year :
- 2018
-
Abstract
- In this study, we describe the frequency of virulence genes in Klebsiella pneumoniae carbapenemase-2-producing Klebsiella pneumoniae (KPC-KP), including hypervirulent (hv) and hypermucoviscous (hm) strains by whole-genome sequencing. We also evaluate the capacity for biofilm formation by using phenotypic techniques. The occurrence of several virulence genes (fimABCDEFGHIK, mrkABCDFHJ, ecpA, wabG, entB, ugE, irp1, irp2, traT, iutA and ureADE) and a high frequency of hvhmKPC-KP isolates was found. Most hospital-associated lineages of KPC-KP belong to the international clonal group 258 (CG258). Biofilm formation was a constant feature among 90.9 % of KPC-KP strains. This report suggests a close relationship between ST437 and weak biofilm production, given that all weakly biofilm-producing strains belonged to this sequence type. This also supports the dissemination of KPC-KP containing numerous virulence determinants belonging to the biofilm-producing CG258 type in Brazil, including hv and hm strains. These factors allow this pathogen to cause infections, leading to its rapid expansion and persistence in hospital settings.
- Subjects :
- Bacterial Proteins genetics
Brazil
Humans
Klebsiella pneumoniae genetics
Klebsiella pneumoniae physiology
Microbial Sensitivity Tests
beta-Lactamases genetics
Bacterial Proteins metabolism
Biofilms
Klebsiella Infections microbiology
Klebsiella pneumoniae enzymology
Klebsiella pneumoniae pathogenicity
beta-Lactamases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5644
- Volume :
- 67
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of medical microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 29509136
- Full Text :
- https://doi.org/10.1099/jmm.0.000711