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I-124 codrituzumab imaging and biodistribution in patients with hepatocellular carcinoma.

Authors :
Carrasquillo JA
O'Donoghue JA
Beylergil V
Ruan S
Pandit-Taskar N
Larson SM
Smith-Jones PM
Lyashchenko SK
Ohishi N
Ohtomo T
Abou-Alfa GK
Source :
EJNMMI research [EJNMMI Res] 2018 Mar 05; Vol. 8 (1), pp. 20. Date of Electronic Publication: 2018 Mar 05.
Publication Year :
2018

Abstract

Background: I-124 codrituzumab (aka GC33), an antibody directed at Glypican 3, was evaluated in patients with hepatocellular carcinoma (HCC). Fourteen patients with HCC underwent baseline imaging with I-124 codrituzumab (~ 185 MBq, 10 mg). Seven of these patients undergoing sorafenib/immunotherapy with 2.5 or 5 mg/kg of cold codrituzumab had repeat imaging, with co-infusion of I-124 codrituzumab, as part of their immunotherapy treatment. Three patients who progressed while on sorafenib/immunotherapy were re-imaged after a 4-week washout period to assess for the presence of antigen. Serial positron emission tomography (PET) imaging and pharmacokinetics were performed following I-124 codrituzumab. An ELISA assay was used to determine "cold" codrituzumab serum pharmacokinetics and compare it to that of I-124 codrituzumab. Correlation of imaging results was performed with IHC. Short-term safety assessment was also evaluated.<br />Results: Thirteen patients had tumor localization on baseline I-124 codrituzumab; heterogeneity in tumor uptake was noted. In three patients undergoing repeat imaging while on immunotherapy/sorafenib, evidence of decreased I-124 codrituzumab uptake was noted. All three patients who underwent imaging after progression while on immunotherapy continued to have I-124 codrituzumab tumor uptake. Pharmacokinetics of I-124 codrituzumab was similar to that of other intact IgG. No significant adverse events were observed related to the I-124 codrituzumab.<br />Conclusions: I-124 codrituzumab detected tumor localization in most patients with HCC. Pharmacokinetics was similar to that of other intact iodinated humanized IgG. No visible cross-reactivity with normal organs was observed.

Details

Language :
English
ISSN :
2191-219X
Volume :
8
Issue :
1
Database :
MEDLINE
Journal :
EJNMMI research
Publication Type :
Academic Journal
Accession number :
29508107
Full Text :
https://doi.org/10.1186/s13550-018-0374-8