Back to Search Start Over

Proteasome 20S in multiple myeloma: comparison of concentration and chymotrypsin-like activity in plasma and serum.

Authors :
Romaniuk W
Kalita J
Ostrowska H
Kloczko J
Source :
Scandinavian journal of clinical and laboratory investigation [Scand J Clin Lab Invest] 2018 Jul; Vol. 78 (4), pp. 253-257. Date of Electronic Publication: 2018 Mar 05.
Publication Year :
2018

Abstract

The ubiquitin-proteasome system is relevant in the pathobiology of many haematological malignancies, including multiple myeloma. The assessment of proteasome concentration and chymotrypsin-like (ChT-L) activity might constitute a new approach to diagnosis, prognosis and monitoring of anticancer treatment of patients with haematological malignancies and other diseases. The aim of our study was to determine which material, plasma or serum, is better for measuring chymotrypsin-like (ChT-L) activity and proteasome concentration. We analysed proteasome concentration and chymotrypsin-like (ChT-L) activity in 70 plasma and serum samples drawn from 28 patients at different treatment stages for multiple myeloma (MM) and 31 healthy volunteers. Proteasome ChT-L activity and concentration in multiple myeloma patients were significantly higher in plasma compared to serum. In this group we observed significant and positive correlations both between the plasma and serum proteasome ChT-L activity and plasma and serum proteasome concentration. The higher values of proteasome concentration and ChT-L activity in plasma than in serum and their better correlations with parameters of tumour load and prognosis suggest that plasma constitutes a better biological material for measuring ChT-L activity and proteasome concentration than serum in multiple myeloma patients.

Details

Language :
English
ISSN :
1502-7686
Volume :
78
Issue :
4
Database :
MEDLINE
Journal :
Scandinavian journal of clinical and laboratory investigation
Publication Type :
Academic Journal
Accession number :
29504425
Full Text :
https://doi.org/10.1080/00365513.2018.1446219