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1,3-Diphenylpropanes from Daphne giraldii induced apoptosis in hepatocellular carcinoma cells through nuclear factor kappa-B inhibition.
- Source :
-
Bioorganic chemistry [Bioorg Chem] 2018 Apr; Vol. 77, pp. 619-624. Date of Electronic Publication: 2018 Feb 16. - Publication Year :
- 2018
-
Abstract
- One new 1,3-diphenylpropane (1) together with six known analogues (2-7) were firstly isolated from the stem and root bark of Daphne giraldii. Their structures were determined by comprehensive NMR and HRESIMS spectroscopic data analyses. All the isolates were evaluated for their cytotoxicity against two hepatocellular carcinoma cell lines (HepG2 and Hep3B). Among them, compound 5 showed the most significant cytotoxicity against Hep3B cells, with an IC <subscript>50</subscript> value of 17.21 μM. A further study demonstrated that 5 obviously induced apoptotic cell death as well as the inactivation of nuclear factor kappa B p65 (NF-κB p65) in Hep3B cells. In addition, BAY 11-7082 (BAY), a NF-кB inhibitor, was used to determine the role of NF-кB signaling in 5-treated Hep3B cells. The results suggested that BAY could enhance 5-induced apoptosis of Hep3B cells. In conclusion, the data provided that 5 might be a potential candidate for the treatment of hepatocellular carcinoma through NF-κB inhibition.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic isolation & purification
Carcinoma, Hepatocellular pathology
Cell Line, Tumor
Cell Proliferation drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Hep G2 Cells
Humans
Liver Neoplasms pathology
Molecular Structure
NF-kappa B metabolism
Propane chemistry
Propane isolation & purification
Propane pharmacology
Structure-Activity Relationship
Antineoplastic Agents, Phytogenic pharmacology
Apoptosis drug effects
Carcinoma, Hepatocellular drug therapy
Daphne chemistry
Liver Neoplasms drug therapy
NF-kappa B antagonists & inhibitors
Propane analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2120
- Volume :
- 77
- Database :
- MEDLINE
- Journal :
- Bioorganic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 29501029
- Full Text :
- https://doi.org/10.1016/j.bioorg.2018.02.017