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Pharmacological prophylaxis of postpartum exacerbation in depressive and anxiety symptoms: a retrospective study.
- Source :
-
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2019 Aug; Vol. 32 (16), pp. 2774-2776. Date of Electronic Publication: 2018 Mar 12. - Publication Year :
- 2019
-
Abstract
- The aim of this study was to investigate the efficacy of prophylactic treatment with antidepressants for the prevention of postpartum exacerbation in depressive or anxiety symptoms. The study included data on 33 patients who were followed from pregnancy to the postpartum period at the Department of Psychiatry of a university Hospital. Psychiatric diagnoses were determined by means of a structured clinical interview. The severity of depressive and anxiety symptoms were assessed by means of Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A), respectively. Prophylactic treatment was initiated within the first 3 days after the delivery. The patients were assessed again with HAM-D and HAM-A at 4-week postpartum. Postpartum prophylaxis was carried out with administration of sertraline at 50 mg/day (n = 7, 21.2%), paroxetine at 20 mg/day (n = 24, 72.7%), and escitalopram at 10 mg/day (n = 2, 6.1%). Statistical analyses indicated that the mean HAM-D and HAM-A scores before (9.45 ± 7.01 and 10.09 ± 6.42, respectively) and after (9.09 ± 6.65 and 9.54 ± 5.97, respectively) the delivery were not significant. Results of the present study suggest that prophylactic use of antidepressants following parturition may be useful in the prevention of postpartum exacerbation of symptoms in women with depression or anxiety disorders.
- Subjects :
- Adult
Anxiety Disorders diagnosis
Anxiety Disorders epidemiology
Comorbidity
Depressive Disorder, Major diagnosis
Depressive Disorder, Major epidemiology
Disease Progression
Female
Humans
Postpartum Period psychology
Pregnancy
Pregnancy Complications
Retrospective Studies
Treatment Outcome
Antidepressive Agents therapeutic use
Anxiety Disorders drug therapy
Depressive Disorder, Major drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1476-4954
- Volume :
- 32
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
- Publication Type :
- Academic Journal
- Accession number :
- 29495902
- Full Text :
- https://doi.org/10.1080/14767058.2018.1447559