Back to Search
Start Over
New Lignans from the Flower of Forsythia koreana and Their Suppression Effect on VCAM-1 Expression in MOVAS Cells.
- Source :
-
Chemistry & biodiversity [Chem Biodivers] 2018 Apr; Vol. 15 (4), pp. e1800026. Date of Electronic Publication: 2018 Apr 17. - Publication Year :
- 2018
-
Abstract
- Six lignans including two new lignans were obtained as the principal components of the Forsythia koreana flowers via silica gel (SiO <subscript>2</subscript> ), octadecyl SiO <subscript>2</subscript> (ODS) as well as Sephadex LH-20 column chromatography. In addition to two new lignans, named koreanaside A ((7R,8S,7'R,8'S)-7,7'-diepoxy-5'-hydroxy-3,3'-dimethoxylignan 4-O-β-d-glucopyranoside) and koreanaside B ((7R,8S,7'S,8'R)-7,9'-epoxy-9,5',7'-trihydroxy-3,3'-dimethoxylignan 4-O-β-d-glucopyranoside), four known lignans were identified to be (+)-phylligenin, (-)-epipinoresinol, pinoresinol, and tinosposide A. The structures and absolute configurations of koreanasides A and B were established by means of analysis of spectroscopic data (NMR, IR, FAB-MS, and CD), whereas the structures of known lignans were identified by comparison their NMR and MS values with those in the reported literature. Their chemical structures including configuration were established by means of analysis of spectroscopic data (NMR, IR, FAB-MS, and CD) but also comparison of their NMR and MS values with those in the reported literature. This is the first article for isolation of six lignans of F. koreana flowers. Koreanasides A and B showed high radical scavenging activity with oxygen radical absorbance capacity (ORAC) values of 0.97 ± 0.01 and 1.02 ± 0.01, respectively. Koreanaside A also prohibited expressing VCAM-1 in MOVAS cells with 80.5% at 25 mg/mL.<br /> (© 2018 Wiley-VHCA AG, Zurich, Switzerland.)
- Subjects :
- Animals
Cells, Cultured
Dose-Response Relationship, Drug
Lignans chemistry
Lignans isolation & purification
Lipopolysaccharides antagonists & inhibitors
Lipopolysaccharides pharmacology
Macrophages drug effects
Macrophages metabolism
Mice
Molecular Structure
Muscle, Smooth, Vascular metabolism
RAW 264.7 Cells
Structure-Activity Relationship
Vascular Cell Adhesion Molecule-1 biosynthesis
Flowers chemistry
Forsythia chemistry
Lignans pharmacology
Muscle, Smooth, Vascular drug effects
Vascular Cell Adhesion Molecule-1 antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1612-1880
- Volume :
- 15
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Chemistry & biodiversity
- Publication Type :
- Academic Journal
- Accession number :
- 29495102
- Full Text :
- https://doi.org/10.1002/cbdv.201800026