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Aspartic acid functionalized PEGylated MSN@GO hybrid as an effective and sustainable nano-system for in-vitro drug delivery.
- Source :
-
Advances in medical sciences [Adv Med Sci] 2018 Sep; Vol. 63 (2), pp. 257-264. Date of Electronic Publication: 2018 Mar 20. - Publication Year :
- 2018
-
Abstract
- Purpose: In this research, aspartic acid functionalized PEGylated mesoporous silica nanoparticlesgraphene oxide nanohybrid (As-PEGylated-MSN@GO) prepared as a pH-responsive drug carrier for the curcumin delivery. For better camouflage during blood circulation, poly(ethylene glycol) was decorated on the surface of MSN@GO nanohybrid.<br />Materials and Methods: The nanocarrier was characterized by using X-ray powder diffraction (XRD), dynamic light scattering (DLS), UV-vis spectroscopy, thermal gravimetry analysis (TGA), FT-IR, SEM and TEM.<br />Results: The size of modified MSN@GO was around 75.8 nm and 24% wt. of curcumin was loaded on the final nanohybrid. pHdecrement from 7.4 to 5.8 the release medium led to increase the cumulative amount of drug release from 54% to 98%.<br />Conclusions: As-functionalized MSN@GO had no cytotoxicity against human breast adenocarcinoma (MCF-7) and human mammary epithelial (MCF10A) as cancerous and normal cell lines, respectively. Whereas curcuminloaded nanohybrid showed excellent killing capability against MCF-7 cells.<br /> (Copyright © 2018 Medical University of Bialystok. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Cell Death drug effects
Cell Survival drug effects
Curcumin pharmacology
Drug Liberation
Dynamic Light Scattering
Humans
MCF-7 Cells
Nanoparticles ultrastructure
Spectroscopy, Fourier Transform Infrared
Static Electricity
Temperature
Thermogravimetry
X-Ray Diffraction
Aspartic Acid chemistry
Drug Delivery Systems
Graphite chemistry
Nanoparticles chemistry
Polyethylene Glycols chemistry
Silicon Dioxide chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1898-4002
- Volume :
- 63
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Advances in medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 29486375
- Full Text :
- https://doi.org/10.1016/j.advms.2018.01.003