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Hypoxia and acidosis: immune suppressors and therapeutic targets.
- Source :
-
Immunology [Immunology] 2018 Jul; Vol. 154 (3), pp. 354-362. Date of Electronic Publication: 2018 Mar 30. - Publication Year :
- 2018
-
Abstract
- Due to imbalances between vascularity and cellular growth patterns, the tumour microenvironment harbours multiple metabolic stressors including hypoxia and acidosis, which have significant influences on remodelling both tumour and peritumoral tissues. These stressors are also immunosuppressive and can contribute to escape from immune surveillance. Understanding these effects and characterizing the pathways involved can identify new targets for therapy and may redefine our understanding of traditional anti-tumour therapies. In this review, the effects of hypoxia and acidosis on tumour immunity will be summarized, and how modulating these parameters and their sequelae can be a useful tool for future therapeutic interventions is discussed.<br /> (© 2018 John Wiley & Sons Ltd.)
- Subjects :
- Acidosis therapy
Animals
Humans
Hypoxia therapy
Immune System cytology
Immune System immunology
Immune System metabolism
Immune Tolerance
Immunologic Surveillance
Immunotherapy
Neoplasms pathology
Neoplasms therapy
Tumor Escape
Acidosis immunology
Acidosis metabolism
Hypoxia immunology
Hypoxia metabolism
Neoplasms etiology
Neoplasms metabolism
Tumor Microenvironment immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2567
- Volume :
- 154
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 29485185
- Full Text :
- https://doi.org/10.1111/imm.12917