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Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2018 Mar 13; Vol. 54 (22), pp. 2792-2795. - Publication Year :
- 2018
-
Abstract
- Dual delivery of dichloroacetate and 5-fluorouracil from Zr MOFs into cancer cells is found to enhance in vitro cytotoxicity. Tuning particle size and, more significantly, surface chemistry, further improves cytotoxicity by promoting caveolae-mediated endocytosis and cytosolic cargo delivery.
- Subjects :
- Antineoplastic Agents chemical synthesis
Antineoplastic Agents chemistry
Cell Proliferation drug effects
Cell Survival drug effects
Dichloroacetic Acid chemistry
Dichloroacetic Acid pharmacology
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Fluorouracil chemistry
Fluorouracil pharmacology
Humans
MCF-7 Cells
Metal-Organic Frameworks chemical synthesis
Metal-Organic Frameworks chemistry
Models, Molecular
Molecular Structure
Structure-Activity Relationship
Zirconium chemistry
Antineoplastic Agents pharmacology
Drug Delivery Systems
Metal-Organic Frameworks pharmacology
Nanoparticles chemistry
Zirconium pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 54
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 29485148
- Full Text :
- https://doi.org/10.1039/c7cc09739e