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Salmonella-Mediated Inflammation Eliminates Competitors for Fructose-Asparagine in the Gut.
- Source :
-
Infection and immunity [Infect Immun] 2018 Apr 23; Vol. 86 (5). Date of Electronic Publication: 2018 Apr 23 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- Salmonella enterica elicits intestinal inflammation to gain access to nutrients. One of these nutrients is fructose-asparagine (F-Asn). The availability of F-Asn to Salmonella during infection is dependent upon Salmonella pathogenicity islands 1 and 2, which in turn are required to provoke inflammation. Here, we determined that F-Asn is present in mouse chow at approximately 400 pmol/mg (dry weight). F-Asn is also present in the intestinal tract of germfree mice at 2,700 pmol/mg (dry weight) and in the intestinal tract of conventional mice at 9 to 28 pmol/mg. These findings suggest that the mouse intestinal microbiota consumes F-Asn. We utilized heavy-labeled precursors of F-Asn to monitor its formation in the intestine, in the presence or absence of inflammation, and none was observed. Finally, we determined that some members of the class Clostridia encode F-Asn utilization pathways and that they are eliminated from highly inflamed Salmonella -infected mice. Collectively, our studies identify the source of F-Asn as the diet and that Salmonella -mediated inflammation is required to eliminate competitors and allow the pathogen nearly exclusive access to this nutrient.<br /> (Copyright © 2018 American Society for Microbiology.)
- Subjects :
- Animals
Inflammation immunology
Inflammation pathology
Salmonella Infections, Animal pathology
Salmonella enterica pathogenicity
Asparagine metabolism
Fructose metabolism
Gastrointestinal Microbiome immunology
Inflammation metabolism
Salmonella Infections, Animal immunology
Salmonella Infections, Animal metabolism
Salmonella enterica immunology
Salmonella enterica metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1098-5522
- Volume :
- 86
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Infection and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 29483291
- Full Text :
- https://doi.org/10.1128/IAI.00945-17