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Postoperative Changes in Metabolic Parameters of Patients with Surgically Controlled Acromegaly: Assessment of New Stringent Cure Criteria.
- Source :
-
Neurologia medico-chirurgica [Neurol Med Chir (Tokyo)] 2018 Apr 15; Vol. 58 (4), pp. 147-155. Date of Electronic Publication: 2018 Feb 23. - Publication Year :
- 2018
-
Abstract
- The criteria for surgical cure of acromegaly have become more stringent during the past decades and a change from Cortina to new consensus criteria has recently been proposed. However, the superiority of the new consensus over Cortina criteria with respect to postoperative metabolic parameters remains to be ascertained. We retrospectively assessed metabolic parameters, the body habitus, and other health-related parameters of 48 patients with surgically controlled acromegaly who met the Cortina criteria [normalized insulin-like growth factor-1 (IGF-1) level and nadir growth hormone (GH) level <1.0 ng/ml during postoperative oral glucose tolerance test]. The 48 patients were divided into two groups. Group A (n = 33) met the new consensus criteria (normalized IGF-1 and nadir GH level <0.4 ng/ml). Group B (n = 15) met Cortina criteria, but their nadir GH ranged from 0.4 to 1.0 ng/ml. In both groups, the level of triglyceride and homeostasis model assessment-insulin resistance (HOMA-IR) was significantly decreased 1 year after the operation (P < 0.05). High-density lipoprotein cholesterol showed a significant increase only in group B (P = 0.02). However, the two groups did not differ with respect to the postoperative improvement rate of these parameters and the other health-related parameters including body mass index, blood pressure, anterior pituitary function, and self-estimated quality of life scale. In conclusion, our findings show that with respect to changes in metabolic parameters and the body habitus assessed 1 year after surgery, the stricter consensus criteria seemed not to be superior to Cortina criteria.
- Subjects :
- Acromegaly physiopathology
Adult
Aged
Blood Pressure
Body Mass Index
Cholesterol, HDL blood
Female
Glucose Tolerance Test
Human Growth Hormone blood
Humans
Insulin Resistance physiology
Insulin-Like Growth Factor I metabolism
Male
Middle Aged
Postoperative Period
Practice Guidelines as Topic
Quality of Life
Retrospective Studies
Treatment Outcome
Triglycerides blood
Acromegaly metabolism
Acromegaly surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1349-8029
- Volume :
- 58
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Neurologia medico-chirurgica
- Publication Type :
- Academic Journal
- Accession number :
- 29479042
- Full Text :
- https://doi.org/10.2176/nmc.oa.2017-0215