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Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis.
- Source :
-
Cell [Cell] 2018 Feb 22; Vol. 172 (5), pp. 1063-1078.e19. - Publication Year :
- 2018
-
Abstract
- Interneurons navigate along multiple tangential paths to settle into appropriate cortical layers. They undergo a saltatory migration paced by intermittent nuclear jumps whose regulation relies on interplay between extracellular cues and genetic-encoded information. It remains unclear how cycles of pause and movement are coordinated at the molecular level. Post-translational modification of proteins contributes to cell migration regulation. The present study uncovers that carboxypeptidase 1, which promotes post-translational protein deglutamylation, controls the pausing of migrating cortical interneurons. Moreover, we demonstrate that pausing during migration attenuates movement simultaneity at the population level, thereby controlling the flow of interneurons invading the cortex. Interfering with the regulation of pausing not only affects the size of the cortical interneuron cohort but also impairs the generation of age-matched projection neurons of the upper layers.<br /> (Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Actomyosin metabolism
Animals
Carboxypeptidases metabolism
Cell Cycle
Chemotactic Factors metabolism
Embryo, Mammalian cytology
Female
Gene Deletion
Interneurons metabolism
Mice
Mice, Knockout
Myosin-Light-Chain Kinase metabolism
Neurogenesis
Phenotype
Cell Movement
Cerebral Cortex cytology
Interneurons cytology
Morphogenesis
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4172
- Volume :
- 172
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cell
- Publication Type :
- Academic Journal
- Accession number :
- 29474907
- Full Text :
- https://doi.org/10.1016/j.cell.2018.01.031