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"Nano-Ginseng" for Enhanced Cytotoxicity AGAINST Cancer Cells.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2018 Feb 23; Vol. 19 (2). Date of Electronic Publication: 2018 Feb 23. - Publication Year :
- 2018
-
Abstract
- Panax ginseng has high medicinal and health values. However, the various and complex components of ginseng may interact with each other, thus reducing and even reversing therapeutic effects. In this study, we designed and fabricated a novel "nano-ginseng" with definite ingredients, ginsenoside Rb1/protopanaxadiol nanoparticles (Rb1/PPD NPs), completely based on the protopanaxadiol-type extracts. The optimized nano-formulations demonstrated an appropriate size (~110 nm), high drug loading efficiency (~96.8%) and capacity (~27.9 wt %), long half-time in systemic circulation (nine-fold longer than free PPD), better antitumor effects in vitro and in vivo, higher accumulation at the tumor site and reduced damage to normal tissues. Importantly, this process of "nano-ginseng" production is a simple, scalable, green economy process.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Animals
Antineoplastic Agents pharmacology
Cell Death drug effects
Cell Line, Tumor
Female
Hemolysis drug effects
Hydrogen-Ion Concentration
Kinetics
Mice, Inbred C57BL
Nanoparticles chemistry
Nanoparticles ultrastructure
Plant Extracts pharmacology
Sapogenins chemistry
Sapogenins pharmacokinetics
Tissue Distribution
Panax chemistry
Sapogenins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 19
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 29473838
- Full Text :
- https://doi.org/10.3390/ijms19020627