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Membrane detachment is not essential for COG complex function.

Authors :
Climer LK
Pokrovskaya ID
Blackburn JB
Lupashin VV
Source :
Molecular biology of the cell [Mol Biol Cell] 2018 Apr 15; Vol. 29 (8), pp. 964-974. Date of Electronic Publication: 2018 Mar 30.
Publication Year :
2018

Abstract

COG is a multisubunit vesicle tethering complex in the Golgi. We demonstrate that both COG subcomplexes can be permanently attached to Golgi membranes and that major COG functions do not require cycling between the membrane and cytosol.

Subjects

Subjects :
Glycosylation
HEK293 Cells
Humans
Protein Subunits metabolism
Protein Transport
Adaptor Proteins, Vesicular Transport metabolism
Golgi Apparatus physiology
Membrane Proteins metabolism
Vesicular Transport Proteins metabolism

Details

Language :
English
ISSN :
1939-4586
Volume :
29
Issue :
8
Database :
MEDLINE
Journal :
Molecular biology of the cell
Publication Type :
Academic Journal
Accession number :
29467253
Full Text :
https://doi.org/10.1091/mbc.E17-11-0694
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