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Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals.
- Source :
-
Nature genetics [Nat Genet] 2018 Mar; Vol. 50 (3), pp. 362-367. Date of Electronic Publication: 2018 Feb 19. - Publication Year :
- 2018
-
Abstract
- Stature is affected by many polymorphisms of small effect in humans <superscript>1</superscript> . In contrast, variation in dogs, even within breeds, has been suggested to be largely due to variants in a small number of genes <superscript>2,3</superscript> . Here we use data from cattle to compare the genetic architecture of stature to those in humans and dogs. We conducted a meta-analysis for stature using 58,265 cattle from 17 populations with 25.4 million imputed whole-genome sequence variants. Results showed that the genetic architecture of stature in cattle is similar to that in humans, as the lead variants in 163 significantly associated genomic regions (P < 5 × 10 <superscript>-8</superscript> ) explained at most 13.8% of the phenotypic variance. Most of these variants were noncoding, including variants that were also expression quantitative trait loci (eQTLs) and in ChIP-seq peaks. There was significant overlap in loci for stature with humans and dogs, suggesting that a set of common genes regulates body size in mammals.
- Subjects :
- Animals
Body Height genetics
Cattle classification
Genetic Association Studies veterinary
Genetic Variation
Humans
Phenotype
Polymorphism, Single Nucleotide
Quantitative Trait Loci genetics
Body Size genetics
Cattle genetics
Conserved Sequence
Genome-Wide Association Study statistics & numerical data
Genome-Wide Association Study veterinary
Mammals genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 50
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Report
- Accession number :
- 29459679
- Full Text :
- https://doi.org/10.1038/s41588-018-0056-5