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Cardiorespiratory noise correction improves the ASL signal.
- Source :
-
Human brain mapping [Hum Brain Mapp] 2018 Jun; Vol. 39 (6), pp. 2353-2367. Date of Electronic Publication: 2018 Feb 15. - Publication Year :
- 2018
-
Abstract
- Cardiorespiratory fluctuations such as changes in heart rate or respiration volume influence the temporal dynamics of cerebral blood flow (CBF) measurements during arterial spin labeling (ASL) fMRI. This "physiological noise" can confound estimates of resting state network activity, and it may lower the signal-to-noise ratio of ASL during task-related experiments. In this study we examined several methods for minimizing the contributions of both synchronized and non-synchronized physiological noise in ASL measures of CBF, by combining the RETROICOR approach with different linear deconvolution models. We evaluated the amount of variance in CBF that could be explained by each method during physiological rest, in both resting state and task performance conditions. To further demonstrate the feasibility of this approach, we induced low-frequency cardiorespiratory deviations via peripheral adrenergic stimulation with isoproterenol, and determined how these fluctuations influenced CBF, before and after applying noise correction. By suppressing physiological noise, we observed substantial improvements in the signal-to-noise ratio at the individual and group activation levels. Our results suggest that variations in cardiac and respiratory parameters can account for a large proportion of the variance in resting and task-based CBF, and indicate that regressing out these non-neuronal signal variations improves the intrinsically low signal-to-noise ratio of ASL. This approach may help to better identify and control physiologically driven activations in ASL resting state and task-based analyses.<br /> (© 2018 Wiley Periodicals, Inc.)
- Subjects :
- Acoustic Stimulation
Adrenergic beta-Agonists pharmacology
Adult
Attention drug effects
Attention physiology
Brain blood supply
Brain drug effects
Cerebrovascular Circulation drug effects
Correlation of Data
Female
Heart Rate drug effects
Humans
Image Processing, Computer-Assisted
Isoproterenol pharmacology
Magnetic Resonance Imaging
Male
Oxygen blood
Pattern Recognition, Visual
Photic Stimulation
Spin Labels
Young Adult
Brain diagnostic imaging
Cerebrovascular Circulation physiology
Heart Rate physiology
Respiration drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0193
- Volume :
- 39
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Human brain mapping
- Publication Type :
- Academic Journal
- Accession number :
- 29450932
- Full Text :
- https://doi.org/10.1002/hbm.24000