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Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization.
- Source :
-
Scientific reports [Sci Rep] 2018 Feb 15; Vol. 8 (1), pp. 3085. Date of Electronic Publication: 2018 Feb 15. - Publication Year :
- 2018
-
Abstract
- Cerebral malaria is a life-threatening complication of Plasmodia infection and a major cause of child mortality in Sub-Saharan Africa. We report that protection from experimental cerebral malaria in the rodent model is obtained by a single intravenous or subcutaneous whole-parasite immunization. Whole-parasite immunization with radiation-attenuated sporozoites was equally protective as immunization with non-attenuated sporozoites under chemoprophylaxis. Both immunization regimens delayed the development of blood-stage parasites, but differences in cellular and humoral immune mechanisms were observed. Single-dose whole-parasite vaccination might serve as a relatively simple and feasible immunization approach to prevent life-threatening cerebral malaria.
- Subjects :
- Animals
CD8-Positive T-Lymphocytes immunology
Disease Models, Animal
Female
Injections, Intravenous
Injections, Subcutaneous
Malaria Vaccines immunology
Malaria, Cerebral immunology
Mice
Mice, Inbred C57BL
Sporozoites immunology
Malaria Vaccines administration & dosage
Malaria, Cerebral parasitology
Malaria, Cerebral prevention & control
Plasmodium berghei immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 8
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 29449638
- Full Text :
- https://doi.org/10.1038/s41598-018-21551-2