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Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma: A Case Report Documenting the Potential for Very Late Tumor Recurrence.
- Source :
-
Head and neck pathology [Head Neck Pathol] 2018 Dec; Vol. 12 (4), pp. 623-628. Date of Electronic Publication: 2018 Feb 14. - Publication Year :
- 2018
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Abstract
- Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma is a peculiar sinonasal tract tumor that demonstrates features of both a surface-derived and salivary gland carcinoma. Implicit in its name, this tumor has a consistent association with high-risk HPV, particularly type 33. It was first described in 2013 under the designation of HPV-related carcinoma with adenoid cystic carcinoma-like features. However, since its initial description additional cases have emerged which demonstrate a wide morphologic spectrum and relatively indolent clinical behavior. Herein we report our experience with a case of HPV-related multiphenotypic sinonasal carcinoma that was initially classified as adenoid cystic carcinoma in the 1980s. The patient recurred after a 30-year disease free interval. RNA in situ hybridization confirmed the presence of high-risk HPV in both her recurrence and her initial tumor in the 1980s, which allowed for reclassification as HPV-related multiphenotypic sinonasal carcinoma. Our case adds to the literature of this relatively newly described entity and supports the indolent clinical behavior of this neoplasm but also demonstrates a potential for very late local recurrence.
Details
- Language :
- English
- ISSN :
- 1936-0568
- Volume :
- 12
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Head and neck pathology
- Publication Type :
- Academic Journal
- Accession number :
- 29445997
- Full Text :
- https://doi.org/10.1007/s12105-018-0895-5