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Neural respiratory drive and cardiac function in patients with obesity hypoventilation syndrome following initiation of non-invasive ventilation.
- Source :
-
Journal of thoracic disease [J Thorac Dis] 2018 Jan; Vol. 10 (Suppl 1), pp. S135-S143. - Publication Year :
- 2018
-
Abstract
- Background: Chronic hypercapnic respiratory failure (HRF) in obesity hypoventilation syndrome (OHS) is commonly treated using non-invasive ventilation (NIV). We hypothesised that treatment of OHS would improve neural respiratory drive index (NRDI) and cardiac function.<br />Methods: Fourteen patients (8 females) with OHS, who were admitted for initiation of domiciliary NIV, were prospectively studied. Patients had (mean ± SD): age (53±10 years), body mass index (BMI) (50.1±10.8 kg/m <superscript>2</superscript> ), and pCO <subscript>2</subscript> (7.3±0.9 kPa). NRDI was assessed by surface electromyogram of the parasternal intercostals. Cardiac function was assessed by transthoracic echocardiography (TTE). All measurements were performed at baseline, 6 weeks, and 3 months.<br />Results: NRDI improved on day one following NIV set-up comparing to baseline (484.2±214.8 vs. 316.5±106.5 AU) and this improvement was maintained at 6 weeks (369.1±173.2 AU) and at 3 months (351.2±167.1 AU) (P=0.004). No significant differences were identified in terms of cardiac function between baseline and 3 months [tricuspid annular plane systolic excursion (TAPSE) (24.6±5.8 vs. 23.0±4.0 mm, P=0.317); systolic pulmonary artery (PA) pressures (36.7±15.2 vs. 44.5±23.9 mmHg, P=0.163].<br />Conclusions: NIV improves NRDI in patients with OHS, while the cardiac function over a three-month period remains unchanged.<br />Competing Interests: Conflicts of Interest: The authors have no conflicts of interest to declare.
Details
- Language :
- English
- ISSN :
- 2072-1439
- Volume :
- 10
- Issue :
- Suppl 1
- Database :
- MEDLINE
- Journal :
- Journal of thoracic disease
- Publication Type :
- Academic Journal
- Accession number :
- 29445537
- Full Text :
- https://doi.org/10.21037/jtd.2017.12.129