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Neural respiratory drive and cardiac function in patients with obesity hypoventilation syndrome following initiation of non-invasive ventilation.

Authors :
Onofri A
Patout M
Kaltsakas G
Lhuillier E
Mushemi-Blake S
Arbane G
Pengo MF
Marino P
Steier J
Source :
Journal of thoracic disease [J Thorac Dis] 2018 Jan; Vol. 10 (Suppl 1), pp. S135-S143.
Publication Year :
2018

Abstract

Background: Chronic hypercapnic respiratory failure (HRF) in obesity hypoventilation syndrome (OHS) is commonly treated using non-invasive ventilation (NIV). We hypothesised that treatment of OHS would improve neural respiratory drive index (NRDI) and cardiac function.<br />Methods: Fourteen patients (8 females) with OHS, who were admitted for initiation of domiciliary NIV, were prospectively studied. Patients had (mean ± SD): age (53±10 years), body mass index (BMI) (50.1±10.8 kg/m <superscript>2</superscript> ), and pCO <subscript>2</subscript> (7.3±0.9 kPa). NRDI was assessed by surface electromyogram of the parasternal intercostals. Cardiac function was assessed by transthoracic echocardiography (TTE). All measurements were performed at baseline, 6 weeks, and 3 months.<br />Results: NRDI improved on day one following NIV set-up comparing to baseline (484.2±214.8 vs. 316.5±106.5 AU) and this improvement was maintained at 6 weeks (369.1±173.2 AU) and at 3 months (351.2±167.1 AU) (P=0.004). No significant differences were identified in terms of cardiac function between baseline and 3 months [tricuspid annular plane systolic excursion (TAPSE) (24.6±5.8 vs. 23.0±4.0 mm, P=0.317); systolic pulmonary artery (PA) pressures (36.7±15.2 vs. 44.5±23.9 mmHg, P=0.163].<br />Conclusions: NIV improves NRDI in patients with OHS, while the cardiac function over a three-month period remains unchanged.<br />Competing Interests: Conflicts of Interest: The authors have no conflicts of interest to declare.

Details

Language :
English
ISSN :
2072-1439
Volume :
10
Issue :
Suppl 1
Database :
MEDLINE
Journal :
Journal of thoracic disease
Publication Type :
Academic Journal
Accession number :
29445537
Full Text :
https://doi.org/10.21037/jtd.2017.12.129