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Plasmacytoid pre-dendritic cells (pDC): from molecular pathways to function and disease association.
- Source :
-
Seminars in cell & developmental biology [Semin Cell Dev Biol] 2019 Feb; Vol. 86, pp. 24-35. Date of Electronic Publication: 2018 Feb 19. - Publication Year :
- 2019
-
Abstract
- Plasmacytoid pre-dendritic cells (pDC) are a specialized DC population with a great potential to produce large amounts of type I interferon (IFN). pDC are involved in the initiation of antiviral immune responses through their interaction with innate and adaptive immune cell populations. In a context-dependent manner, pDC activation can induce their differentiation into mature DC able to induce both T cell activation or tolerance. In this review, we described pDC functions during immune responses and their implication in the clearance or pathogenicity of human diseases during infection, autoimmunity, allergy and cancer. We discuss recent advances in the field of pDC biology and their implication for future studies.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1096-3634
- Volume :
- 86
- Database :
- MEDLINE
- Journal :
- Seminars in cell & developmental biology
- Publication Type :
- Academic Journal
- Accession number :
- 29444460
- Full Text :
- https://doi.org/10.1016/j.semcdb.2018.02.014